Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC024
Test administered by neuromedic@manusdevices.net
Test date and time 2022-07-28 16:26
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment Tbl Madopar 250mg 3x1/4

Overall Assessment

non PD

Subject performance similar to non PD population

Clinical context

In the clinical reference population, 19 individuals with a value less than 0.57 were subsequently diagnosed with PD. That is, 45.24% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.57 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 1, 'TN': 2, 'TP': 41, 'FP': 28}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 39, 'TN': 28, 'TP': 3, 'FP': 2}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 30, 'TN': 25, 'TP': 12, 'FP': 5}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 18, 'TN': 10, 'TP': 24, 'FP': 20}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 15.296
timePerCircleCoV 0.0880292
timePerCircleSlope -0.00963611
meanError 0.99784
tremorFreq 6.25
tremorRelPower 74.6766
tremorGyroAmpMean 0.0863672
tremorGyroAmpSlope -0.00234463
tremorGyroAmpCoV 0.446834
tremorCoordAmpMean 0.141934
tremorCoordAmpSlope -0.00204838
tremorCoordAmpCoV 0.316308
tremorAccAmpMean 0.155449
tremorAccAmpSlope -0.0018404
tremorAccAmpCoV 0.226274
tremorPcRelVar 0.791564
tremorPcX -0.23534
tremorPcY 0.971913

Circle Segment 1

Duration 14.24 s, Accuracy Estimate 1.155 (lower is better)

Circle Segment 2

Duration 15.0 s, Accuracy Estimate 0.876 (lower is better)

Circle Segment 3

Duration 16.04 s, Accuracy Estimate 0.982 (lower is better)

Circle Segment 4

Duration 16.4 s, Accuracy Estimate 0.859 (lower is better)

Circle Segment 5

Duration 17.96 s, Accuracy Estimate 0.706 (lower is better)

Circle Segment 6

Duration 15.52 s, Accuracy Estimate 0.935 (lower is better)

Circle Segment 7

Duration 14.72 s, Accuracy Estimate 0.901 (lower is better)

Circle Segment 8

Duration 15.52 s, Accuracy Estimate 0.732 (lower is better)

Circle Segment 9

Duration 14.56 s, Accuracy Estimate 0.839 (lower is better)

Circle Segment 10

Duration 13.0 s, Accuracy Estimate 1.993 (lower is better)

Spiral

numSpirals 5
timePerSpiralMean 43.168
timePerSpiralCoV 0.0567485
timePerSpiralSlope -0.00963677
meanError 1.58428
tremorFreq 5.66406
tremorRelPower 60.2675
tremorGyroAmpMean 0.139916
tremorGyroAmpSlope 0.00200907
tremorGyroAmpCoV 0.746189
tremorCoordAmpMean 0.152426
tremorCoordAmpSlope 0.0010906
tremorCoordAmpCoV 0.504793
tremorAccAmpMean 0.167553
tremorAccAmpSlope 0.000721815
tremorAccAmpCoV 0.391713
tremorPcRelVar 0.733509
tremorPcX -0.0611317
tremorPcY 0.99813

Spiral Segment 1

Duration 45.32 s, Accuracy Estimate 1.508 (lower is better)

Spiral Segment 2

Duration 40.64 s, Accuracy Estimate 1.66 (lower is better)

Spiral Segment 3

Duration 43.44 s, Accuracy Estimate 1.723 (lower is better)

Spiral Segment 4

Duration 45.76 s, Accuracy Estimate 1.522 (lower is better)

Spiral Segment 5

Duration 40.68 s, Accuracy Estimate 1.509 (lower is better)

Elel

eDurationMean 1.03872
eDurationStd 0.18241
eDurationStdnorm 0.17561
eDurationMedian 1.005
eDurationQuartdelta 0.28625
eDurationQuartdeltanorm 0.284826
eDurationKurt 3.78863
eDurationTrenddiff -0.03
eDurationTrendratio 0.970149
eWidthMean 8.061
eWidthStd 2.03108
eWidthStdnorm 0.251964
eWidthMedian 7.839
eWidthQuartdelta 2.7495
eWidthQuartdeltanorm 0.350746
eWidthKurt 2.1517
eWidthTrenddiff -1.17
eWidthTrendratio 0.864865
eHeightMean 11.43
eHeightStd 2.31806
eHeightStdnorm 0.202805
eHeightMedian 11.349
eHeightQuartdelta 3.59775
eHeightQuartdeltanorm 0.31701
eHeightKurt 1.97223
eHeightTrenddiff 0.936
eHeightTrendratio 1.08696
eAspectMean 0.707892
eAspectStd 0.120866
eAspectStdnorm 0.17074
eAspectMedian 0.716418
eAspectQuartdelta 0.143207
eAspectQuartdeltanorm 0.199893
eAspectKurt 3.00843
eAspectTrenddiff -0.134779
eAspectTrendratio 0.826316
eSlantMean 0.269943
eSlantStd 0.192953
eSlantStdnorm 0.714791
eSlantMedian 0.274809
eSlantQuartdelta 0.233704
eSlantQuartdeltanorm 0.850422
eSlantKurt 2.51602
eSlantTrenddiff -0.0958824
eRtopMean 0.835365
eRtopStd 0.102393
eRtopStdnorm 0.122573
eRtopMedian 0.849057
eRtopQuartdelta 0.161452
eRtopQuartdeltanorm 0.190155
eRtopKurt 3.27105
eRtopTrenddiff -0.0320513
eRbotMean 0.46762
eRbotStd 0.188214
eRbotStdnorm 0.402493
eRbotMedian 0.42029
eRbotQuartdelta 0.21565
eRbotQuartdeltanorm 0.513099
eRbotKurt 2.5947
eRbotTrenddiff 0.0460505
eRrightMean 0.894378
eRrightStd 0.0655678
eRrightStdnorm 0.0733111
eRrightMedian 0.905882
eRrightQuartdelta 0.0879727
eRrightQuartdeltanorm 0.0971128
eRrightKurt 2.77538
eRrightTrenddiff -0.00948922
eRleftMean 0.302998
eRleftStd 0.100453
eRleftStdnorm 0.33153
eRleftMedian 0.28
eRleftQuartdelta 0.0984904
eRleftQuartdeltanorm 0.351751
eRleftKurt 4.78604
eRleftTrenddiff 0.0417116
lDurationMean 1.32125
lDurationStd 0.231009
lDurationStdnorm 0.174841
lDurationMedian 1.295
lDurationQuartdelta 0.3025
lDurationQuartdeltanorm 0.233591
lDurationKurt 2.83454
lDurationTrenddiff -0.1425
lDurationTrendratio 0.896739
lWidthMean 14.0342
lWidthStd 2.4818
lWidthStdnorm 0.17684
lWidthMedian 13.689
lWidthQuartdelta 2.34
lWidthQuartdeltanorm 0.17094
lWidthKurt 4.09196
lWidthTrenddiff 0.234
lWidthTrendratio 1.01709
lHeightMean 26.4742
lHeightStd 4.26409
lHeightStdnorm 0.161066
lHeightMedian 25.5645
lHeightQuartdelta 5.499
lHeightQuartdeltanorm 0.215103
lHeightKurt 3.69689
lHeightTrenddiff -0.234
lHeightTrendratio 0.990868
lAspectMean 0.533637
lAspectStd 0.0724941
lAspectStdnorm 0.135849
lAspectMedian 0.537618
lAspectQuartdelta 0.105144
lAspectQuartdeltanorm 0.195575
lAspectKurt 3.02227
lAspectTrenddiff -0.000206946
lAspectTrendratio 0.999615
lSlantMean 0.304284
lSlantStd 0.0846808
lSlantStdnorm 0.278295
lSlantMedian 0.298682
lSlantQuartdelta 0.111758
lSlantQuartdeltanorm 0.37417
lSlantKurt 2.98982
lSlantTrenddiff 0.00871599
lRtopMean 0.872524
lRtopStd 0.0569201
lRtopStdnorm 0.0652361
lRtopMedian 0.878431
lRtopQuartdelta 0.0605948
lRtopQuartdeltanorm 0.0689807
lRtopKurt 3.18387
lRtopTrenddiff -0.0041004
lRbotMean 0.307081
lRbotStd 0.0897262
lRbotStdnorm 0.292191
lRbotMedian 0.309019
lRbotQuartdelta 0.137844
lRbotQuartdeltanorm 0.446071
lRbotKurt 2.53297
lRbotTrenddiff 0.0137306
lRrightMean 0.903762
lRrightStd 0.0417002
lRrightStdnorm 0.0461406
lRrightMedian 0.90219
lRrightQuartdelta 0.0659984
lRrightQuartdeltanorm 0.0731536
lRrightKurt 2.65369
lRrightTrenddiff 0.0104989
lRleftMean 0.187222
lRleftStd 0.0486764
lRleftStdnorm 0.259993
lRleftMedian 0.185774
lRleftQuartdelta 0.0587149
lRleftQuartdeltanorm 0.316055
lRleftKurt 3.31813
lRleftTrenddiff 0.0262712

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.811369
sumTouchScores 11.3592
meanMovementTime 1.46462
numTouches 14
undershootPercentage 0
overshootPercentage 35.7143

FITTS Long Modified

meanTouchScore 0.842215
sumTouchScores 10.9488
meanMovementTime 1.66
numTouches 13
undershootPercentage 7.69231
overshootPercentage 23.0769

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 45.48
timePerZigzagCoV 0.0778799
timePerZigzagSlope -0.0452067
meanError 2.18335
tremorFreq 5.17578
tremorRelPower 58.9941
tremorGyroAmpMean 0.178326
tremorGyroAmpSlope -0.00215632
tremorGyroAmpCoV 1.66047
tremorCoordAmpMean 0.178023
tremorCoordAmpSlope 0.000606177
tremorCoordAmpCoV 0.750762
tremorAccAmpMean 0.206816
tremorAccAmpSlope -0.00312197
tremorAccAmpCoV 1.43285
tremorPcRelVar 0.786848
tremorPcX -0.634527
tremorPcY -0.772901

ZigZag Segment 1

Duration 50.88 s, Accuracy Estimate 2.731 (lower is better)

ZigZag Segment 2

Duration 45.28 s, Accuracy Estimate 1.845 (lower is better)

ZigZag Segment 3

Duration 45.8 s, Accuracy Estimate 1.894 (lower is better)

ZigZag Segment 4

Duration 44.4 s, Accuracy Estimate 2.157 (lower is better)

ZigZag Segment 5

Duration 41.04 s, Accuracy Estimate 2.29 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 21.816
timePerZigzagCoV 0.16897
timePerZigzagSlope -0.096443
zigzagHeightMean 50.0529
zigzagHeightCoV 0.145725
zigzagHeightSlope -0.0752279
meanError 0.0401268
tremorFreq 6.25
tremorRelPower 38.8165
tremorGyroAmpMean 0.180256
tremorGyroAmpSlope -0.000944964
tremorGyroAmpCoV 0.616562
tremorCoordAmpMean 0.263591
tremorCoordAmpSlope 0.00136018
tremorCoordAmpCoV 0.397099
tremorAccAmpMean 0.262883
tremorAccAmpSlope -0.00129953
tremorAccAmpCoV 0.528899
tremorPcRelVar 0.851199
tremorPcX 0.0191335
tremorPcY -0.999817

ZigZag Offset Segment 1

Duration 26.24 s, Accuracy Estimate 0.047 (lower is better)

ZigZag Offset Segment 2

Duration 22.56 s, Accuracy Estimate 0.022 (lower is better)

ZigZag Offset Segment 3

Duration 24.2 s, Accuracy Estimate 0.026 (lower is better)

ZigZag Offset Segment 4

Duration 18.16 s, Accuracy Estimate 0.058 (lower is better)

ZigZag Offset Segment 5

Duration 17.92 s, Accuracy Estimate 0.049 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘PD’, ‘HiSpec_score’: 0.27}
RanFor {‘RanFor_class’: ‘NOT PD’, ‘RanFor_score’: 0.57}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.09881950847424736}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9333073080060315}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.4247561539670084}